OLIGONUCLEOTIDE ANALYSIS BY CAPILLARY ZONE ELECTROPHORESIS AT LOW PH

Authors
DEBELLIS G SALANI G
Citation
G. Debellis et G. Salani, OLIGONUCLEOTIDE ANALYSIS BY CAPILLARY ZONE ELECTROPHORESIS AT LOW PH, Analytica chimica acta, 345(1-3), 1997, pp. 1-4
Citations number
3
Categorie Soggetti
Chemistry Analytical
Journal title
Analytica chimica acta → ACNP
ISSN journal
00032670
Volume
345
Issue
1-3
Year of publication
1997
Pages
1 - 4
Database
ISI
SICI code
0003-2670(1997)345:1-3<1:OABCZE>2.0.ZU;2-D
Abstract
We present a method to determine oligonucleotide purity by means of ca pillary electrophoresis in free solution at low pH. The separation pri nciple is based on the differential protonation of nucleobases. Result s on a large set of samples demonstrate the interest of this technique for routine quality control.