Costimulation of T cells

Authors
Bugeon, L Dallman, MJ
Citation
L. Bugeon et Mj. Dallman, Costimulation of T cells, AM J R CRIT, 162(4), 2000, pp. S164-S168
Citations number
49
Categorie Soggetti
Cardiovascular & Respiratory Systems","da verificare
Journal title
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
ISSN journal
1073449X → ACNP
Volume
162
Issue
4
Year of publication
2000
Supplement
S
Pages
S164 - S168
Database
ISI
SICI code
1073-449X(200010)162:4<S164:COTC>2.0.ZU;2-F
Abstract
Costimulation is critical to T cell activation. On the antigen-presenting c ell the key players are found in the extended family of B7 genes comprising cd80, cd86, B7h/B7RP-1 and B7-H1. cd80 and cd86 encode proteins that bind to CD28 and CTLA4 on T cells. Blocking this pathway with the potent CTLA4-I g fusion protein shows encouraging potential as a therapeutic: agent. While cd80 and cd86 pathways act mainly on naive T cells, B7h/B7RP-1 and B7-H1 s eem to exert their effects on antigen-experienced lymphocytes.