Concomitant well-differentiated adenocarcinoma and leiomyosarcoma of the uterus

We describe a case of a concomitant well-differentiated endometrial endomet rioid adenocarcinoma and leiomyosarcoma of the uterus in a 66-year-old woma n who presented with a 6-month history of vaginal bleeding. The patient und erwent total hysterectomy for endometrial carcinoma diagnosed by endometria l biopsy. Gross examination of the specimen revealed an endometrial mass bu lging into the endometrial cavity and an underlying well-circumscribed nodu le separated from the endometrial mass by a myometrial band. Frozen section performed at the time of the total hysterectomy rendered a diagnosis of ma lignant mixed-mullerian tumor. Histologic examination of the permanent sect ions revealed well-differentiated endometrial endometrioid adenocarcinoma c learly separated from a high-grade leiomyosarcoma. Differential diagnosis i ncluded malignant mixed-mullerian tumor. However, no admixture of carcinoma tous and sarcomatous elements was present. There were no heterologous eleme nts. To the best of our knowledge, no similar case has been described in th e English literature.