Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives

Authors
Bharti, N Maurya, MR Naqvi, F Azam, A
Citation
N. Bharti et al., Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives, BIOORG MED, 10(20), 2000, pp. 2243-2245
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
20
Year of publication
2000
Pages
2243 - 2245
Database
ISI
SICI code
0960-894X(20001016)10:20<2243:SAAAON>2.0.ZU;2-7
Abstract
Reaction of [RU(eta (4)-C8H12) (CH3CN)(2) Cl-2] with 2-(2-pyridyl) benzimid azole or Schiff bases derived from 2-acetylpyridine and S-methyldithiocarba zate, S-benzyldithiocarbazate and thiosemicarbazide leads to form new compl exes of the type [RU(eta (4-) C8H12)(L)Cl-2] (where L=ligand). In vitro, mo st of the compounds exhibited potent activity and the Ru derivatives 1a [RU (eta (4)- C8H12)(2-Acpy-SMDT)Cl-2, 2a [Ru(eta (4)-C8H12)(2-Acpy-SBDT)Cl-2] and 3a [Ru(eta (4)-C8H12)(2-Acpy-TSC)Cl-2] were found more active than metr onidazole against (HK-9) strain of Entamoeba histolytica. (C) 2000 Elsevier Science Ltd. All rights reserved.