DNA tripler structures are stabilized by the incorporation of 3 '-endo blocked pyrimidine nucleosides in the Hoogsteen strand

Authors
Savy, P Benhida, R Fourrey, JL Maurisse, R Sun, JS
Citation
P. Savy et al., DNA tripler structures are stabilized by the incorporation of 3 '-endo blocked pyrimidine nucleosides in the Hoogsteen strand, BIOORG MED, 10(20), 2000, pp. 2287-2289
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
20
Year of publication
2000
Pages
2287 - 2289
Database
ISI
SICI code
0960-894X(20001016)10:20<2287:DTSASB>2.0.ZU;2-0
Abstract
A short route to pyrimidine locked nucleosides has been developed for their incorporation in tripler forming oligonucleotides (TFO). Compared to oligo nucleotides built with standard nucleosides, the modified TFOs containing 3 '-endo blocked residues formed, with their corresponding DNA duplexes, more stable triple helix systems, an effect which might be ascribed to the 3'-e ndo pucker of the modified nucleoside residues. (C) 2000 Elsevier Science L td. All rights reserved.