(E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: Synthesis,cytotoxic activity and antitumor activity

Authors
You, YJ Kim, Y Song, GY Ahn, BZ
Citation
Yj. You et al., (E)-6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: Synthesis,cytotoxic activity and antitumor activity, BIOORG MED, 10(20), 2000, pp. 2301-2303
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
20
Year of publication
2000
Pages
2301 - 2303
Database
ISI
SICI code
0960-894X(20001016)10:20<2301:(S>2.0.ZU;2-H
Abstract
All of 13 (E)-6-(1-alkyloxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone de rivatives synthesized showed high ED,ED50 values, ranging from 0.1 to 0.3 m ug/mL against L1210 cells. However, they were inactive on A549 cells. Nine compounds exhibited higher T/C (%) values (318-388%) than Adriamycin (T/C, 315%). (C) 2000 Elsevier Science Ltd. All rights reserved.