The design and synthesis of novel NK1/NK2 dual antagonists

Authors
Reichard, GA Ball, ZT Aslanian, R Anthes, JC Shih, NY Piwinski, JJ
Citation
Ga. Reichard et al., The design and synthesis of novel NK1/NK2 dual antagonists, BIOORG MED, 10(20), 2000, pp. 2329-2332
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
20
Year of publication
2000
Pages
2329 - 2332
Database
ISI
SICI code
0960-894X(20001016)10:20<2329:TDASON>2.0.ZU;2-G
Abstract
Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 ha s resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class. The addition of the amino or the ox ime functional group results in the reversal of the stereochemical preferen ce of the NK2 receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.