Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines

Authors
Ting, PC Lee, JF Anthes, JC Shih, NY Piwinski, JJ
Citation
Pc. Ting et al., Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines, BIOORG MED, 10(20), 2000, pp. 2333-2335
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
20
Year of publication
2000
Pages
2333 - 2335
Database
ISI
SICI code
0960-894X(20001016)10:20<2333:SANRAO>2.0.ZU;2-U
Abstract
A series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]3-(3,4-dichloropheny l)-4(Z)-(methoxyimino)pentyl-1-piperazines was prepared and their affinity for the NK1 and NK2 receptors investigated. Compounds 7f: 10o, 10r, and 10s were found to be our most potent inhibitors. (C) 2000 Elsevier Science Ltd . All rights reserved.