Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2

Authors
Walker, CV Caravatti, G Denholm, AA Egerton, J Faessler, A Furet, P Garcia-Echeverria, C Gay, B Irving, E Jones, K Lambert, A Press, NJ Woods, J
Citation
Cv. Walker et al., Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2, BIOORG MED, 10(20), 2000, pp. 2343-2346
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
20
Year of publication
2000
Pages
2343 - 2346
Database
ISI
SICI code
0960-894X(20001016)10:20<2343:SDASOP>2.0.ZU;2-B
Abstract
A series of novel phosphinates, derived from 4-phosphonomethylphenylalanine , are described as isosteres of phosphotyrosine. Benzyl (or alkyl) phosphin omethylphenylalanine derivatives were prepared by alkylation of an amino ac id P-H phosphinate. (C) 2000 Elsevier Science Ltd. All rights reserved.