Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives

Authors
Jorgensen, AS Jacobsen, P Christiansen, LB Bury, PS Kanstrup, A Thorpe, SM Naerum, L Wassermann, K
Citation
As. Jorgensen et al., Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives, BIOORG MED, 10(20), 2000, pp. 2383-2386
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
20
Year of publication
2000
Pages
2383 - 2386
Database
ISI
SICI code
0960-894X(20001016)10:20<2383:SAERBA>2.0.ZU;2-S
Abstract
A series of pyrrolo[2,1,5-cd]indolizine derivatives has been synthesized an d evaluated as ligands for the estrogen receptor. Properly substituted mono - and di-hydroxy derivatives showed binding in the low nanomolar range in a ccordance with their structural resemblance to estrogen. (C) 2000 Elsevier Science Ltd. All rights reserved.