Objective To assess the role of mitozantrone, active in relapsed prostate c
ancer, as an adjuvant to hormonal treatment in patients with advanced prost
ate cancer.
Patients and methods Between October 1990 and May 1995, 96 patients were en
tered into a stratified, randomized, single-institution study of hormonal t
herapy with a luteinizing hormone-releasing hormone agonist and flutamide,
with or without four cycles of adjuvant mitozantrone. Of these, 93 patients
were evaluable and the results were analysed in June 1999.
Results Patients with localized prostate cancer receiving adjuvant chemothe
rapy had a higher initial objective response rate (95% vs 53%, P = 0.008) a
nd median survival (80 vs 36 months, P = 0.04) than patients who were treat
ed with hormonal therapy alone. There was no advantage to adjuvant chemothe
rapy in patients with metastatic prostate cancer. There were insignificant
advantages to chemotherapy in overall response rates (55% vs 39%, P = 0.3)
and PSA responses (82% vs 64%, P = 0.11). There was no difference between t
he patient groups in time to treatment failure.
Conclusion There was a survival advantage in using adjuvant mitozantrone in
patients with locally advanced prostate cancer. Although the study compris
ed relative few patients, the follow-up period was long and the advantage s
ignificant. We recommend that the study be extended to include more patient
s.