Al. Rice et al., Malnutrition as an underlying cause of childhood deaths associated with infectious diseases in developing countries, B WHO, 78(10), 2000, pp. 1207-1221
Citations number
64
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Introduction Recent estimates suggest that malnutrition (measured as poor a
nthropometric status) is associated with about 50% of all deaths among chil
dren. Although the association between malnutrition and all-cause mortality
is well documented, the malnutrition-related risk of death associated with
specific diseases is less well described. We reviewed published literature
to examine the evidence for a relation between malnutrition and child mort
ality from diarrhoea, acute respiratory illness, malaria and measles, condi
tions that account for over 50% of deaths in children worldwide.
Methods MEDLINE was searched for suitable review articles and original repo
rts of community-based and hospital-based studies. Findings from cohort stu
dies and case-control studies were reviewed and summarized.
Results The strongest and most consistent relation between malnutrition and
an increased risk of death was observed for diarrhoea and acute respirator
y infection. the evidence, although limited, also suggests a potentially in
creased risk for death from malaria. A less consistent association was obse
rved between nutritional status and death from measles. Although some hospi
tal-based studies and case-control studies reported an increased risk of mo
rtality from measles, few community-based studies reported any association.
Discussion The risk of malnutrition-related mortality seems to vary for dif
ferent diseases. These findings have important implications for the evaluat
ion of nutritional intervention programmes and child survival programmes be
ing implemented in settings with different disease profiles.