Spectrophotometric (UV) and chromatographic (HPLC) methods for determination of loratadine hydrochloride in pharmaceutical preparations. Validation of the methods

Authors
Nogowska, M Zajac, M Muszalska, I
Citation
M. Nogowska et al., Spectrophotometric (UV) and chromatographic (HPLC) methods for determination of loratadine hydrochloride in pharmaceutical preparations. Validation of the methods, CHEM ANAL, 45(5), 2000, pp. 681-688
Citations number
3
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHEMIA ANALITYCZNA
ISSN journal
00092223 → ACNP
Volume
45
Issue
5
Year of publication
2000
Pages
681 - 688
Database
ISI
SICI code
0009-2223(2000)45:5<681:S(AC(M>2.0.ZU;2-F
Abstract
Spectrophotometric (UV) and chromatographic (HPLC) methods were applied to the determination of loratadine hydrochloride in tablets and in suspension. The use of the HPLC method required the optimization of the composition of the mobile phase. The relationship between drug concentrations and peaks a rea, the accuracy, precision were rested by using the reference model mixtu res.