Effects of somatosensory input on central fatigue: a pilot study

Objective: Depression of motor evoked potentials (MEPs) following transcran ial magnetic stimulation (TMS) may be a sign of central motor fatigue. As a pilot study, we have examined whether post-exercise MEP depression can be compensated by application of sensory stimuli prior to TMS. Methods: We studied 15 healthy volunteers (aged 21-28 years) who were requi red to perform an exercise protocol of ankle dorsiflexion until force fell below 66% of maximum force. MEPs were recorded from the right tibialis ante rior muscle. Prior to TMS, electrical stimuli were applied to the ipsilater al sural nerve with an individual interstimulus interval between 50 and 80 ms. Results: MEP areas decreased after exercise. When a sensory stimulus was ad ministered MEPs did not change. Conclusion: We conclude that the effects of central fatigue may be influenc ed by application of sensory stimuli. (C) 2000 Elsevier Science Ireland Ltd . All rights reserved.