The genus Dorstenia contains many plants that are used as anti-snakebite, a
nti-infection and anti-rheumatic remedies in the medicinal plant therapy of
many countries in Africa, Central and South America. The genus is now reco
gnized as a rich source of prenyl and geranyl-substituted coumarins, chalco
nes, flavones and flavanones. The first examples of naturally occurring sty
renes (2 and 3) were reported from D. barnimiana. The geranyl substituted f
urocoumarin (5) has been found in many species. D. poinsettifolia furnished
the unusual 4-phenyl substituted dihydrocoumarin, and the rare geranyl and
prenyl substituted chalcone (17). Prenylated flavonoids have so far been r
eported from African Dorstenia only. Compound 18 from D. proropens is the o
nly example of a bis-geranylated chalcone in the literature. D. manni furni
shed the novel chalcone (13), 6-prenylchrysoeriol (22 R = OMe), the geranyl
derivative (43), eight diprenylated flavanones (28, 30-36) and one flavono
l (29). These dorsmannins appear to be derived from 6,8-diprenyleriodictyol
and a possible biosynthetic scheme for them is presented (Fig. 5). Compoun
d 21 was reported from D. zenkeri and is believed to arise from 20. The lat
ter is probably formed via an enzymatic Diels-Alder reaction of isobavachal
cone (10) and its dehydroderivative (19). D. psilurus provided all the trip
renylated compounds (37-42) found in Dorstenia and, of these, 42 is unique
in having ring B of the flavonoid structure modified to a dienone. The phar
macological data on this genus are scanty. Extracts of D. multiradiata show
antileishmanial activity. Extracts and/or compounds from other species sho
w anti-inflammatory, analgesic, anti-oxidant and cytotoxic activities.