Infrequency of pulmonary microbial colonisation prior to respiratory disease in HIV-infected individuals

Citation
Mci. Lipman et al., Infrequency of pulmonary microbial colonisation prior to respiratory disease in HIV-infected individuals, EUR J CL M, 19(9), 2000, pp. 699-703
Citations number
15
Categorie Soggetti
Microbiology
Journal title
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
ISSN journal
09349723 → ACNP
Volume
19
Issue
9
Year of publication
2000
Pages
699 - 703
Database
ISI
SICI code
0934-9723(200009)19:9<699:IOPMCP>2.0.ZU;2-R
Abstract
To determine whether organisms are present in the HIV-infected lung prior t o clinical respiratory disease, a cross-sectional bronchoscopic comparative analysis of 39 asymptomatic HIV-positive subjects and 31 healthy controls with 2-year prospective bronchoscopic monitoring of the HIV study group was performed. Pathological examination of bronchoalveolar lavage (BAL) fluid using standard microbiological techniques was undertaken. Organisms were re covered from similar numbers of HIV-positive and control subjects (7 of 39 and 3 of 31) and comprised predominantly scanty growths of bacteria. Five s ubjects developed respiratory disease during follow-up. Repeat BAL was perf ormed in 11 asymptomatic HIV-positive patients; no relationship was found b etween the organisms isolated at the two procedures. The findings suggest t hat the asymptomatic HIV-positive lung is not a frequent site of either mic robial colonisation or subclinical infection. This has implications for the understanding of the pathogenesis of HIV-related pulmonary disease.