Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

Obejective: Firstly, to study the effect of tea and tea polyphenols on card iovascular risk indicators of the inflammatory system (IL6, IL1 beta and TN F-alpha, CRP), and on haemostasis and endothelial proteins with an acute ph ase behaviour (fibrinogen, vWF, PAI-I, FVIIa and u-PA). Secondly, to study the relationship between plasma levels of antioxidants (alpha-tocopherol, b eta-carotene and Vitamin C) and these acute-phase, cardiovascular risk indi cators. Design: Randomized study. Subjects: Sixty-four smoking healthy volunteers were recruited by newspaper advertisements; there were five dropouts. Intervention: Four-week administration of black tea, green tea, green tea p olyphenol isolate and mineral water (13-16 per group). Measures: Plasma levels of the inflammatory markers IL6, IL1 beta, TNF-alph a, CRP, fibrinogen, vWF, PAI-1, FVIIa and u-PA. and of the antioxidants h-t ocopherol, beta-carotene and vitamin C. Results: Different dosages of tea polyphenols had no effect on inflammation , haemostasis and endothelial markers. There was a significant negative cor relation between the levels of the antioxidant beta-carotene and the inflam mation markers IL6 and fibrinogen (r = -0.35 and r = -0.37, respectively, P < 0.01) in this group of smokers. Remarkably, there was a significant posi tive correlation between the levels of the antioxidant alpha-tocopherol and the inflammation marker IL6 (r = 0.28, P < 0.05). Conclusions: Tea drinking had no effect on the levels of the inflammation, haemostasis and endothelial cardiovascular risk factors measured. We did ob serve a relationship between the antioxidant variables alpha-tocopherol and beta-carotene and inflammation markers in this group of healthy smoking su bjects.