Type I interferons and T helper development

Authors
Farrar, JD Murphy, KM
Citation
Jd. Farrar et Km. Murphy, Type I interferons and T helper development, IMMUNOL TOD, 21(10), 2000, pp. 484-489
Citations number
50
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
10
Year of publication
2000
Pages
484 - 489
Database
ISI
SICI code
0167-5699(200010)21:10<484:TIIATH>2.0.ZU;2-G
Abstract
Type I interferons (IFN-ls) activate Stat4 and promote Th1 development in h uman, but not mouse, CD4(+) T cells. Recently, IFN-1-induced Stat4 activati on in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine ann human Stat2 explains th e ability of human, but not mouse, CD4(+) T cells to undergo IFN-1-induced Stat4 activation and Th1 development.