The CD4/CD8 lineage decision: integration of signalling pathways

Authors
Basson, MA Zamoyska, R
Citation
Ma. Basson et R. Zamoyska, The CD4/CD8 lineage decision: integration of signalling pathways, IMMUNOL TOD, 21(10), 2000, pp. 509-514
Citations number
44
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
10
Year of publication
2000
Pages
509 - 514
Database
ISI
SICI code
0167-5699(200010)21:10<509:TCLDIO>2.0.ZU;2-U
Abstract
An immature CD4(+)CD8(+) thymocyte mn differentiate into a functionally spe cialized CD4(+) or CD8(+) T cell. The molecular mechanisms underlying this CD4/CD8 lineage choice are poorly understood. Recent evidence suggests that thymocytes are sensitive to subtle variations in signal intensity and that lineage choice might be the consequence of the integration of signals eman ating from multiple pathways.