Prevalence of GB virus C/hepatitis G virus RNA and anti-E2 glycoprotein antibodies in homosexual men with HIV coinfection

Background: The objective of this cross-sectional, nonrandomized, prospecti ve study was to generate data on the prevalence of CB virus C (GBV-C)/hepat itis C virus (HCV) in a cohort of HIV-infected homosexuals from Munich. Patients: A total of 71 HIV-infected homosexual men were analyzed for preva lence of GBV-C RNA and antibodies to the E-2 envelope glycoprotein (E2Ab). 475 healthy volunteer blood donors in southern Bavaria served as a control group. Results: The prevalence of GBV-C RNA was 27% (control group: 2.3%) and the prevalence of E2Ab was 35% (control group: 6%). The total prevalence for pr esent and past infection was 62%. The differences between the HIV-infected patients and the control group were significant (p < 0.0001). GBV-C RNA and E2Ab were not detected simultaneously in any serum sample. The E2Ab positi ve patients were older than the GBV-C RNA positives (mean 46 years versus 3 9 years, p = 0.0350). The GBV-C RNA and E2Ab negative patients were older t han the GBV-C RNA positives (mean 47 yea rs versus 39 years, p = 0.0236). T he E2Ab positive patients had suffered sexually transmitted diseases more f requently than the patients negative for markers of GBV-C infection (p = 0. 0308). E2Ab positive patients also had higher mean levels of alanine aminot ransferase compared to patients without evidence of GBV-C infection (p = 0. 0164). 59-4% of all individuals were anti-HBc IgG positive. Conclusion: The data can be interpreted as indirect evidence for sexual tra nsmission of GBV-C.