Capillary electrophoretic separation of the enantiomers of organophosphates with a phosphorus stereogenic center using the sodium salt of octakis(2,3-diacetyl-6-sulfo)-gamma-cyclodextrin as resolving agent

The sodium salt of the single-isomer, chiral resolving agent, octakis(2,3-d iacetyl-6-sulfo)-gamma -cyclodextrin (ODAS-gamma CD) has been used for the capillary electrophoretic separation of the enantiomers of alkylarylphospha tes which carry a phosphorus-based stereogenic center. The effective mobili ties and separation selectivities were measured at different ODAS-gamma CD and methanol concentrations to find the conditions under which the minor en antiomers could be adequately quantitated in samples obtained by chemical r esolution of the racemic mixtures. This work extends the utility of ODAS-ga mma CD to a hitherto unexplored field, the capillary electrophoretic separa tion of the enantiomers of organophosphorus compounds. (C) 2000 Elsevier Sc ience B.V. All rights reserved.