Regression of left ventricular hypertrophy in hypertensive patients treated with indapamide SR 1.5 mg versus enalapril 20 mg: the LIVE study

Citation
P. Gosse et al., Regression of left ventricular hypertrophy in hypertensive patients treated with indapamide SR 1.5 mg versus enalapril 20 mg: the LIVE study, J HYPERTENS, 18(10), 2000, pp. 1465-1475
Citations number
36
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF HYPERTENSION
ISSN journal
02636352 → ACNP
Volume
18
Issue
10
Year of publication
2000
Pages
1465 - 1475
Database
ISI
SICI code
0263-6352(200010)18:10<1465:ROLVHI>2.0.ZU;2-8
Abstract
Objective To compare the efficacy of indapamide sustained release (SR) 1.5 mg and enalapril 20 mg at reducing left ventricular mass index (LVMI) in hy pertensive patients with left ventricular hypertrophy (LVH). Design The LIVE study (left ventricular hypertrophy regression, indapamide versus enalapril) was a 1 year, prospective, randomized, double-blind study . For the first time, a committee validated LVH before inclusion, provided on-going quality control during the study, and performed an end-study readi ng of all echocardiograms blinded to sequence. Setting European hospitals, general practitioners and cardiologists. Patients Hypertensive patients aged greater than or equal to 20 years with LVH (LVMI in men >120 g/m(2); LVMI in women >100 g/m(2)). Data were obtaine d from 411 of 505 randomized patients. Interventions Indapamide SR 1.5 mg, or enalapril 20 mg, daily for 48 weeks. Main outcome measures LVMI variation in the per-protocol population. Results Indapamide SR 1.5 mg significantly reduced LVMI (-8.4 +/- 30.5 g/m( 2) from baseline; P < 0.001), but enalapril 20 mg did not (-1.9 +/- 28.3 g/ m(2)). Indapamide SR 1.5 mg reduced LVMI significantly more than enalapril 20 mg: -6.5 g/m(2), P = 0.013 (-4.8 g/m(2) when adjusted for baseline value s; P = 0.049). Both drugs equally and significantly reduced blood pressures (P < 0.007), without correlation with LVMI changes. Indapamide SR progress ively reduced wall thicknesses throughout the 1-year treatment period. In c ontrast the effect of enalapril observed at 6 months was not maintained at 12 months. Conclusions Indapamide SR 1.5 mg was significantly more effective than enal april 20 mg at reducing LVMI in hypertensive patients with LVH. J Hypertens 18:1465-1475 (C) 2000 Lippincott Williams & Wilkins.