M. Kato et al., Augmented response in plasma brain natriuretic peptide to dynamic exercisein patients with left ventricular dysfunction and congestive heart failure, J INTERN M, 248(4), 2000, pp. 309-315
Citations number
35
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Objectives. We have previously demonstrated that patients with symptomatic
congestive heart failure (CHF), but not with asymptomatic left ventricular
dysfunction (LVD), have augmented plasma atrial natriuretic peptide (ANP) r
esponse to exercise. Plasma brain natriuretic peptide (BNP) response to exe
rcise is less extensively studied. The aim of this study was to determine w
hether responses of plasma BNP during exercise normalized for exercise work
load are altered in patients with LVD and CHF.
Subjects and methods. Twenty-nine patients with LVD, 32 patients with CHF (
NYHA classes II-III) and 27 age-matched control subjects were studied. Vent
ilatory, plasma ANP and BNP responses were assessed during symptom-limited
cardiopulmonary exercise testing. Plasma natriuretic peptide levels were me
asured at rest and immediately after peak exercise. The increment in plasma
BNP was divided by the increment in oxygen uptake (VO2) from rest to peak
exercise, and this ratio [BNP exercise ratio: (peak BNP - rest BNP)/(peak V
O2 - rest VO2)] was compared amongst the three groups.
Results. Peak VO2 (Control, LVD and CHF: 28.2 +/- 1.7, 21.1 +/- 1.8, 16.2 /- 0.6 mL min(-1) kg(-1), respectively), anaerobic threshold and peak workl
oad became smaller as heart failure worsened. Resting and peak plasma ANP l
evels were significantly higher only in CHF, whilst resting and peak plasma
BNP levels displayed a significant and continuous increase from normal sub
jects to LVD and CHF. The ANP exercise ratio (1.25 +/- 0.36, 2.61 +/- 0.57,
7.72 +/- 1.65, anova P = 0.0002) was significantly higher only in patients
with CHF, whilst the BNP exercise ratio (0.35 +/- 0.10, 2.60 +/- 0.69, 4.9
8 +/- 0.97, anova P = 0.0001) was significantly higher in patients with LVD
and became progressively higher in patients with CHF.
Conclusions. These data showed that the BNP exercise ratio, an exercise pla
sma BNP response normalized with exercise workload, was augmented in patien
ts with LVD, and became progressively higher in CHF, suggesting that an aug
mented exercise BNP ratio exists early in the course of developing CHF.