Comparison of postoperative acute-phase reactants in patients who underwent laparoscopic v open cholecystectomy: A randomized study

Purpose: We investigated the effect of laparoscopic v open cholecystectomy on acute-phase reactants, Patients and Methods: Fifty patients were randomized to laparoscopic (Group 1) and 50 to open (Group 2) cholecystectomy, Preoperative and postoperativ e values for acute-phase reactants (ceruloplasmin, fibrinogen, Westergren s edimentation rate, alpha-1-antitrypsin, haptoglobin, and C-reactive protein ) in blood samples were compared. Results: Acute-phase reactants and length of hospitalization were significa ntly lower in patients who underwent a laparoscopic cholecystectomy than in those who underwent an open cholecystectomy, Conclusion: Laparoscopic cholecystectomy appears associated with a less int ense stress response and less tissue damage than open cholecystectomy.