Can kinetic analysis be a tool for evaluating pore characteristics?

As the pore morphology influences drug release, the purpose is to study por e characteristics by comparing bead performances. Casein/gelatin beads have been prepared by the emulsification extraction method, cross-linked with D ,L-glyceraldehyde in acetone:water mixture 3:1 (v/v) and loaded with sodium fluorescein as a model drug. The beads with higher casein percentage have a higher matrix porosity, a wider average pore diameter and a higher cross- linking degree. The higher casein percentage causes a lower drug release ra te. The kinetic analysis shows that the drug release occurs bq diffusion an d that the diffusion coefficient is affected by the casein percentage and t he cross-linking degree. It can be hypothesized that the pore and channel m orphology (tortuosity.), due to the casein percentage in the matrix and the cross-linking treatment, can he evaluated by kinetic analysis of the relea se data.