K. Sanada et al., High production of beta-thujaplicin with Thuja dolabrata var. hondai cellsin a semi-continuous culture system, J MOL CAT B, 11(1), 2000, pp. 59-61
Cultured cells of Thuja dolabrata var. hondai, which were able to produce b
eta -thujaplicin in high yield, were induced and selected. The effective pr
oduction and extraction of beta -thujaplicin has been achieved using the cu
ltured cells in a semi-continuous culture system. This system needs only th
e whole cells without immobilizing them and the flesh medium in each batch
production. The productive efficiency did not decrease during repetitive ba
tch production. (C) 2000 Elsevier Science B.V. All rights reserved.