Kf. Koral et al., Initial results for hybrid SPECT-conjugate-view tumor dosimetry in I-131-anti-B-1 antibody therapy of previously untreated patients with lymphoma, J NUCL MED, 41(9), 2000, pp. 1579-1586
Citations number
23
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
A study of the use of I-131-labeled anti-B-1 monoclonal antibody, proceeded
by an unlabeled predose, for therapy of previously untreated non-Hodgkin's
lymphoma patients has recently been completed at the University of Michiga
n, Ann Arbor. More than half of the patients treated were imaged intrathera
py with SPECT to separate apparently large tumors, unresolved by conjugate
views, into individual ones specified by CT scan. The dosimetry of these tu
mors is reported here. Methods: The activity-quantification procedure used
3-dimensional CT-to-SPECT fusion so that attenuation maps could be computed
from CT and that volumes of interest could be drawn on the CT slices and t
ransferred to the SPECT images. Daily conjugate-view images after a tracer
dose of labeled anti-B-1 antibody followed by an unlabeled predose provided
the shape of the time-activity curve for the calculation of therapy dosime
try. Reconstructed SPECT counts that were within a volume of interest were
converted to activity by using a background-and-radius-adaptive conversion
factor. Activities were increased for tumors less than 200 g using a recove
ry-coefficient factor derived from activity measurements for a set of spher
es with volumes ranging from 1.6 to 200 cm(3). The calculated tumor radiati
on absorbed dose was based, in part, on the CT volume and on the intrathera
py-SPECT activity. Results: The mean of the radiation dose values for 131 a
bdominal or pelvic tumors in 31 patients was 616 cGy with a standard deviat
ion of +/-50 cGy. The largest dose was 40 Gy and the smallest dose was 73 c
Gy. The mean volume for the tumors was 59.2 +/- 11.2 cm(3). The correlation
coefficient between absorbed dose and tumor volume was small (r(2) = 0.007
), and the slope of the least-squares fit represented a decrease of only 36
.4 cGy per 100 cm(3) increase in volume. This small slope may reflect a cha
racteristic of anti-B-1 antibody therapy that is important for its success.
The mean absorbed dose per unit administered activity was 1.83 +/- 0.145 G
y/GBq. The largest Value was 12.6 Gy/GBq, and the smallest value was 0.149
Gy/GBq. The mean dose for 9 axillary tumors in 5 patients was significantly
lower than the average dose for abdominal and pelvic tumors (P = 0.01). Th
erefore, axillary tumors should be grouped separately in assessing dose-res
ponse relationships. Anecdotal patient results tended to verify the validit
y of using the shape of the conjugate-view time-activity curve for the aver
age SPECT-intratherapy curve. However, there was also an indication that th
e shape Varies somewhat for individual tumors with respect to time to peak.
Conclusion: Hybrid SPECT-conjugate-view dosimetry provided radiation absor
bed dose estimates for the individual patient tumors that were resolved by
CT.