A LOW-ENERGY SHORT HYDROGEN-BOND IN VERY HIGH-RESOLUTION STRUCTURES OF PROTEIN-RECEPTOR PHOSPHATE COMPLEXES

Authors
WANG ZM LUECKE H YAO NH QUIOCHO FA
Citation
Zm. Wang et al., A LOW-ENERGY SHORT HYDROGEN-BOND IN VERY HIGH-RESOLUTION STRUCTURES OF PROTEIN-RECEPTOR PHOSPHATE COMPLEXES, Nature structural biology, 4(7), 1997, pp. 519-522
Citations number
26
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
7
Year of publication
1997
Pages
519 - 522
Database
ISI
SICI code
1072-8368(1997)4:7<519:ALSHIV>2.0.ZU;2-R
Abstract
A very short hydrogen bond between an Asp and a phosphate is establish ed in two high resolution structures (0.98 and 1.05 Angstrom). A mutan t complex that changes the Asp to an Asn,which forms a normal hydrogen bond, has a similar free energy of binding to the wild type complex, suggesting that the contribution of the short hydrogen bond is not ext raordinarily strong.