In PET, inorganic scintillator crystals are used to record gamma-rays produ
ced by the annihilation of positrons emitted by injected tracers. The ultim
ate performance of the camera is strongly tied to both the physical and sci
ntillation properties of the crystals. For this reason, researchers have in
vestigated virtually all known scintillator crystals for possible use in PE
T. Despite this massive research effort, only a few different scintillators
have been found that have a suitable combination of characteristics, and o
nly 2 (thallium-doped sodium iodide and bismuth germanate) have found wides
pread use. A recently developed scintillator crystal, cerium-doped lutetium
oxyorthosilicate, appears to surpass all previously used materials in most
respects and promises to be the basis for the next generation of PET camer
as.