CONTROLLED-RELEASE OF CISPLATIN INCORPORATED INTO BIODEGRADABLE POLY-D,1-LACTIC ACID

Using a melt-pressing technique, we produced a small solid cylinder co ntaining cisplatin (CDDP) embedded in poly-d,l-lactic acid (CDDP-PLA). The in vitro release of CDDP from the polymer was examined in an imme rsion system. CDDP was released continuously for more than four weeks with no initial burst. Drug distribution for CDDP-PLA was compared wit h CDDP solution (CDDP-SOL) by subcutaneous administration into the bac k of rats. In the CDDP-PLA group, a high concentration of CDDP was mai ntained in the subcutaneous tissues near the implants for 20 days. How ever, in the CDDP-SOL group, the concentration of CDDP was low by 10 d ays after drug administration. CDDP-PLA may become a useful tool in lo coregional chemotherapy as a solid type of drug delivery system with l onglasting release.