ANTIPROLIFERATIVE EFFECTS OF AN ORGANIC EXTRACT FROM THE MARINE DIATOM SKELETONEMA-COSTATUM (GREV) CLEVE AGAINST A NON-SMALL-CELL BRONCHOPULMONARY CARCINOMA LINE (NSCLC-N6)

Authors
BERGE JP BOURGOUGNON N CARBONNELLE D LEBERT V TOMASONI C DURAND P ROUSSAKIS C
Citation
Jp. Berge et al., ANTIPROLIFERATIVE EFFECTS OF AN ORGANIC EXTRACT FROM THE MARINE DIATOM SKELETONEMA-COSTATUM (GREV) CLEVE AGAINST A NON-SMALL-CELL BRONCHOPULMONARY CARCINOMA LINE (NSCLC-N6), Anticancer research, 17(3C), 1997, pp. 2115-2120
Citations number
23
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
17
Issue
3C
Year of publication
1997
Pages
2115 - 2120
Database
ISI
SICI code
0250-7005(1997)17:3C<2115:AEOAOE>2.0.ZU;2-S
Abstract
An organic extract of the marine diatom Skeletonema costatum was studi ed in vitro for its effect on asynchronous cells of a human non-small- cell bronchoplumanory carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G(1) phase of the cell cycle, and kinetic studi es in pretreated cells showed that this growth arrest was irreversible . These events are related to a terminal maturation induction.