Thirty-five boxers that had been referred to the Royal (Dick) School of Vet
erinary Studies between 1989 and 1994 with left heart base murmurs and aort
ic velocities greater than 1.5 m/second on Doppler echocardiography were re
called for clinical examination and Doppler echocardiography between 1995 a
nd 1996. Five dogs (14 per cent) showed an increase in murmur grade on repe
at visit. Six dogs (17 per cent) showed an increase in aortic velocity of g
reater than 20 per cent. Eight dogs (23 per cent) had developed aortic valv
ular or subvalvular two-dimensional echocardiographic changes that had not
been present at the initial visit. Seven dogs (20 per cent) had developed a
ortic regurgitation, and three dogs (8 per cent) mitral regurgitation.