In an attempt to better understand the troubling issue of renal human
papillomavirus (HPV) infection, fresh tumour specimens obtained by sur
gical extirpation from tumours were compared for the presence of HPV.
All of the renal carcinoma samples were examined by PCR using two sets
of consensus primers and the specific primer pairs for HPV 16, 18, an
d 33. None of the 28 carcinomas and 17 corresponding normal tissues we
re found positive for HPV DNA in any of the applied analyses. Our resu
lts suggest that HPV does not play any role in the development of rena
l carcinoma in the general population.