3-Acyl-4-diphenylmethyl-2-(N-cyanoimino)thiazolidine: An enantioselective acylation reagent for racemic amines

Authors
Tanaka, T Fang, X Azuma, T Uchida, S Ishida, T In, Y Iwata, C Maezaki, N
Citation
T. Tanaka et al., 3-Acyl-4-diphenylmethyl-2-(N-cyanoimino)thiazolidine: An enantioselective acylation reagent for racemic amines, J CHIN CHEM, 47(4B), 2000, pp. 865-868
Citations number
32
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
ISSN journal
00094536 → ACNP
Volume
47
Issue
4B
Year of publication
2000
Pages
865 - 868
Database
ISI
SICI code
0009-4536(200008)47:4B<865:3AEA>2.0.ZU;2-V
Abstract
(S)-3-Acyl-4-diphenylmethyl-2-(N-cyanoimino)thiazolidine was found to be an effective enantioselective acylation reagent for racemic amines. 3-Benzoyl derivative was found to realize up to 79% ee upon acylation of (+/-)-1-phe nylethylamine.