Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease

Authors
Siebner, HR Rossmeier, C Mentschel, C Peinemann, A Conrad, B
Citation
Hr. Siebner et al., Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease, J NEUR SCI, 178(2), 2000, pp. 91-94
Citations number
11
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN journal
0022510X → ACNP
Volume
178
Issue
2
Year of publication
2000
Pages
91 - 94
Database
ISI
SICI code
0022-510X(20000915)178:2<91:SMIAS5>2.0.ZU;2-2
Abstract
Ten unmedicated patients with Parkinson's disease received sub-threshold 5- Hz repetitive transcranial magnetic stimulation (rTMS) over the primary mot or hand area (M1(HAND)) contralaterally to the more affected upper limb. Co mpared to a midfrontal sham-rTMS, real-rTMS over M1(HAND) was associated wi th a significant decrease in the global motor UPDRS score 1 h after the ces sation of rTMS. This was mainly due to a clinical improvement in the arm co ntralaterally to the stimulated M1(HAND). These preliminary data suggest th at focal rTMS of M1(HAND) may have a therapeutic potential in PD. (C) 2000 Elsevier Science B.V. All rights reserved.