MALE BREAST-CANCER - PATHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES

Background: Male breast cancer is uncommon and studies regarding the p otential clinical relevance of the histopathological and immunohistoch emical features are infrequently reported. Materials and Methods. We i nvestigated the biological characteristics of forty-one male patients with invasive breast cancer by assessing histopathological and multipl e immunohistochemical features. Results. The majority wets no special type (ductal) (37/41), lobular cancer was not seen. 73% were histologi cal grade 3, 93% were positive for oestrogen receptor and 73% for prog esterone receptor. The proportion of cancers positive for c-erbB-2 (45 %), EGFR (20%), p53 (58%), MiB1 (40%), NCRC11 (78%), were similar to r eports for female breast cancer. Nonsignificant associations between p ool survival outcome and grade 3 tumours, and positive tissue staining for MiB1 and p53 were seen. Conclusions. While there are similarities in the biological features of breast cancel in males and females, som e differences were identified Male breast cancer is more likely to be grade 3 tumours and hormone receptor positive.