Bifonazole-beta-cyclodextrin inclusion complexes. Thermal analysis and X-ray powder diffraction study

The complexation of bifonazole, an antimycotic hydrophobic imidazole deriva tive, with beta -cyclodextrin (beta -CD) was investigated in solid phase, u sing the following complementary techniques: differential scanning calorime try (DSC), thermogravimetric analysis (TG) and X-ray powder diffractometry. The beta -CD-bifonazole samples were prepared in both aqueous medium by co precipitation and in solid state by kneading method and the beta -CD-bifona zole binary diagrams were drawn. The experimental results demonstrate the f ormation of two binary compounds, beta -CD-bifonazole and (beta -CD)(x)bifo nazole (x=2 or 4). The first compound may be an inclusion compound and the second a crystallized compound, in which the bifonazole is not necessarily included in the cyclodextrin internal cavity.