Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis

Authors
Coyle, N Jones, I Roberson, E Lendon, C Craddock, N
Citation
N. Coyle et al., Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis, LANCET, 356(9240), 2000, pp. 1490-1491
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
356
Issue
9240
Year of publication
2000
Pages
1490 - 1491
Database
ISI
SICI code
0140-6736(20001028)356:9240<1490:VATSTG>2.0.ZU;2-N
Abstract
Up to half of parous females with bipolar disorder (manic depression) devel op an episode of severe psychiatric disturbance, usually called puerperal p sychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substa ntial (odds ratio=4) and important. (population attributable fraction=69%) influence on susceptibility to such episodes.