Electroreduction and quantification of furazolidone and furaltadone in different media

Adsorptive cathodic stripping voltammetry was used for the determination of furazolidone (FZ) and furaltadone (FD) in borax and phosphate buffers, res pectively, using HMDE as working electrode. The influence of different fact ors upon the peak current response such as accumulation potential, scan rat e, preconcentration time, pH and other variables was studied. Furazolidone and furaltadone showed an adsorption character on HMDE in pres ence of borax and phosphate buffers, respectively. A single cathodic peak a t -0.36 V in borax (pH = 9.5) was observed for FZ, while FD gave a cathodic peak at -0.32 V in phosphate buffer (pH = 8.5). The calibration graph showed a linear behavior over the range 3 x 10(-9)-9 x 10(-8) mol dm(-3) for furazolidone. In the case of FD, concentrations fro m 3 x 10(-9) to 2 x 10(-7) mol dm(-3) gave a linear relationship with the p eak current. A detection limit of 2 x 10(-9) mol dm(-3) anal 1 x 10(-9) mol dm(-3) was obtained for furazolidone and furaltadone, respectively. This m ethod was applied to determine these drugs in pharmaceutical formulations, urine and serum samples.