MATURATION OF THE MAMMALIAN DORSAL-ROOT ENTRY ZONE - FROM ENTRY TO NOENTRY

Interfaces between glial cell precursors of the PNS and CNS are establ ished early in development and form the sites where sensory axons ente r and motor axons exit the developing CNS. The molecular and cellular interactions that lead to the formation of these glial interfaces are only now becoming apparent. New in-vitro techniques are providing clue s as to how the maturation of PNS-CNS glial interfaces generates barri ers to regenerating axons.