High-intensity focused ultrasound in prostate cancer: Results after 3 years

Background: Local high-intensity focused ultrasound (HIFU) is a minimally i nvasive method of coagulation (85 degrees C) that ablates prostatic tissue with high precision. Patients and Methods: Over a 3-year period, 184 patients with organ-confine d prostate cancer have undergone 232 sessions of transrectal HIFU therapy ( mean duration 90 minutes) under spinal anesthesia at 2.25 or 3.0 MHz, 50 W, with a penetration depth of 25 mm, Results: Follow-up sextant biopsies (mean 1.9) were cancer free in 80% of p atients, and in patients with residual cancer, the tumor mass was reduced m ore than 90%. The nadir value of prostate specific antigen (PSA) was <4 ng/ mL in 97%, including 61% who had values < 0.5 ng/mL. After primary HIFU, no severe side effects (fistula, grade 2 or 3 incontinence, rectal mucosal bu rn) were seen. All patients had a suprapubic tube (mean 29 days), and 33% n eeded transurethral resection of debris (mean 7 g), Hospital discharge was within 23 hours after treatment. Conclusion: Transrectal HIFU enables minimally invasive local prostate tiss ue ablation with high rates of negative biopsies, low PSA nadir, and low co mplication rate, Further follow-up is needed to define the efficacy of dise ase control.