No role for the ryanodine receptor in regulating cardiac contraction?

Authors
Eisner, DA Trafford, AW
Citation
Da. Eisner et Aw. Trafford, No role for the ryanodine receptor in regulating cardiac contraction?, NEWS PHYSL, 15, 2000, pp. 275-279
Citations number
12
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
15
Year of publication
2000
Pages
275 - 279
Database
ISI
SICI code
0886-1714(200010)15:<275:NRFTRR>2.0.ZU;2-W
Abstract
Cardiac contraction is initiated by Ca2+ leaving the sarcoplasmic reticulum through the ryanodine receptor (RyR). Although opening of the RyR can be m odified by various ligands, these have no maintained effect on contraction. We conclude that modulation of the RyR controls sarcoplasmic reticulum Ca2 + content rather than cytoplasmic Ca2+ concentration.