Citation
J. Berges et al., Influence of protonation on the stability of disulfide radicals, NUKLEONIKA, 45(1), 2000, pp. 23-29
Citations number
33
Categorie Soggetti
Physics
Journal title
NUKLEONIKA
ISSN journal
00295922
→ ACNP
Volume
45
Issue
1
Year of publication
2000
Pages
23 - 29
Database
ISI
SICI code
0029-5922(2000)45:1<23:IOPOTS>2.0.ZU;2-4
Abstract
The ease of disulfide bond cleavage in peptides and proteins is evaluated b
y an experimental method (one-electron reduction by COO.- radicals and meas
urement of the chain length) and two theoretical approaches based on quantu
m chemistry and topology. All results agree to show acid-catalysis of this
bond opening. The disulfide bond in the radical state is weakened by proton
ation.