Expression of cytokeratin 1, 5, 14, 19 and transforming growth factors-beta 1, beta 2, beta 3 in osteofibrous dysplasia and adamantinoma: A possible association of transforming growth factor-beta with basal cell phenotype promotion

To elucidate the precise origin and characteristics of the epithelial compo nents of osteofibrous dysplasia (OF) and adamantinoma (AD), the expression of transforming growth factor (TGF)-beta1, beta2 and beta3 and cytokeratin (CK) subtypes were studied in five cases of AD and 18 cases of OF by immuno histochemistry. CK1 was expressed in 10 out of 18 OF cases; CK5 was express ed in one OF case; CK14 was positively stained in 10 cases of OF; CK19 was positively stained in 16 OF cases; CK1 was expressed in three out of five A D cases; CK5 was expressed in one case of AD; CK14 was positively stained i n four AD cases; and CK19 was positively stained in five AD cases. In OF, T GF-beta1, beta2 and beta3 were expressed in both fibroblasts and osteoblast s. In AD, TGF-beta1, beta2 and beta3 were expressed in both epithelial and fibrous components. These results suggest that epithelial components of AD and OF share epidermal characteristics, CK1, express basal cell phenotype a nd cytokeratins 5, 14 and 19. In addition to these epithelial characteristi cs, strong immunoreactivity for TGF-beta poses the possibility of TGF-beta promotion of basal cell phenotype expression for the epithelial components in OF and AD.