Role of infection in the development of acquired subglottic stenosis in neonates with prolonged intubation

Objective: To examine whether clinically diagnosed infection correlates wit h subsequent development of subglottic stenosis in intubated neonates. Methods: Sixty-two neonatal infants intubated for more than 14 days were ex amined. Several risk factors for subglottic stenosis, including infection, duration of intubation, frequency of intubation, the size of the endotrache al tube etc., were evaluated by multiple logistic regression analysis. Results: Infection that occurred within 14 days of intubation showed a posi tive correlation with subsequent subglottic stenosis. The duration of intub ation, frequency of intubation and the size of the endotracheal tube did no t affect the development of subglottic stenosis. The majority of infections were considered to be respiratory tract infections, including pneumonia. Conclusions: Infection occurring within 14 days of intubation is considered to be a risk factor for acquired subglottic stenosis in neonates intubated for more than 14 days. Prevention of infection within 14 days of intubatio n may reduce the incidence of subglottic stenosis in neonates.