A case of temporal lobe epilepsy with improvement of clinical symptoms andsingle photon emission computed tomography findings after treatment with clonazepam

A 26-year-old female presented psychomotor seizures, deja vu and amnestic s yndrome after meningitis at the age of 14 years. Repeated electroencephalog rams (EEG) demonstrated occasional spikes localized in the right temporal r egion in addition to a considerable amount of theta waves mainly in the rig ht fronto-temporal region. Single photon emission computed tomography (SPEC T) showed a marked hypoperfusion corresponding to the region in which the E EG showed abnormal findings, although magnetic resonance imaging (MRI) demo nstrated no abnormal findings associated with the clinical features. Treatm ent with clonazepam in addition to sodium valproate resulted in a remarkabl e improvement of clinical symptoms (i.e. psychomotor seizures and deja vu), as well as of the EEG and SPECT findings. The present study suggests that SPECT is a useful method not only to determine the localization of regions associated with temporal lobe epilepsy but also to evaluate the effect of t reatment in temporal lobe epilepsy.