We aimed to test the efficacy of amantadine in chronic hepatitis C (CHC) pa
tients infected with genotype Ib. Twenty patients completed treatment with
amantadine HCl, 100 mg b.i.d., for 6 months. Non-sustained biochemical impr
ovement was observed without loss of HCV-RNA, We conclude that amantadine m
onotherapy is not effective in CHC.