A DECREASE IN LEFT-VENTRICULAR HYPERTROPH Y AND A TREND IN PARAMETERSOF 24-H AP MONITORING IN PATIENTS WITH ESSENTIAL-HYPERTENSION ON RAMIPRIL

To evaluate factors of action of ramipril, an inhibitor of angiotensin -converting enzyme, which may induce a decrease in left ventricular hy pertrophy (LVH), 45 LVH patients aged 21-53 years with mild and modera te essential hypertension have underwent echo-CG determination of left ventricular mass and 24-h monitoring of arterial pressure (AP). Multi ple regression was used to examine prognostic significance of such par ameters as age, sex, height, weight, duration of the disease, mean 24- h AP, its variability and the degree of nocturnal fall. It was found t hat ramipril reduced LVH irrespective of the hypotensive effect.