Synthesis and regioselective alkylation of 1,6-and 1,7-naphthyridines

Authors
Colandrea, VJ Naylor, EM
Citation
Vj. Colandrea et Em. Naylor, Synthesis and regioselective alkylation of 1,6-and 1,7-naphthyridines, TETRAHEDR L, 41(42), 2000, pp. 8053-8057
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
42
Year of publication
2000
Pages
8053 - 8057
Database
ISI
SICI code
0040-4039(20001014)41:42<8053:SARAO1>2.0.ZU;2-S
Abstract
A regioselective alkylation of naphthyridines 4a-d, through the action of e thylchloroformate and benzylstannane 5, afforded the benzyl substituted dih ydronaphthyridines 3a-d. These key intermediates 3a-d were transformed into the desired targets 2a-d in seven steps. (C) 2000 Elsevier Science Ltd. Al l rights reserved.