Synthesis of aspartimide-free protected peptides on base-labile functionalized resins

Authors
Rabanal, F Pastor, JJ Nicolas, E Albericio, F Giralt, E
Citation
F. Rabanal et al., Synthesis of aspartimide-free protected peptides on base-labile functionalized resins, TETRAHEDR L, 41(42), 2000, pp. 8093-8096
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
42
Year of publication
2000
Pages
8093 - 8096
Database
ISI
SICI code
0040-4039(20001014)41:42<8093:SOAPPO>2.0.ZU;2-O
Abstract
Aspartimide prone sequence containing protected peptides are successfully s ynthesized in solid phase by using the bifunctional linker N-[(9-hydroxymet hyl)-2-fluorenyl] succinamic acid (HMFS) in combination with morpholine as the cleavage reagent. Access to high purity peptide synthons opens a straig htforward way to the synthesis of large proteins by convergent strategies. (C) 2000 Elsevier Science Ltd. All rights reserved.